Well, our friend on Twitter @SonOfFritz gave us this artwork for the whistling rectal rocket novelty item, being produced by our friend Danny in Canada. If the dumb things never make it to market, this cover art made me very, very happy.
September 28, 2015
September 2, 2015
Please Help Our Friend Tracy DeMarzo
Our friend, Tracy DeMarzo (many of you know her as Rick Shapiro’s wife) is battling breast cancer and has a GoFundMe account for her surgery and reconstruction. To quote Tracy:
For those of you that know me, you know that I have great self-body-image. And yes, many of you have seen my boobs! Which makes me love them more. I have been on stages as a stripper, I have been to Fantasy Fest in Key West, wet t-shirt contests, naked piano dancing.. it was all me. But more importantly, my breasts have given me access to great self body image has lent hand in my confidence, my self-esteem.. and more so, my ability to love myself.
I am seeking enough money to see a specific Doctor. Any monies raised additionally will go to charity. As well, I will be participating in a photo-shoot which will carry the Breast Cancer logo and I am hoping to auction those off, signed. My last hope is to organize a comedy show all about boobs.
You all know our position on Weird Medicine, we support boobs under all circumstances, and friends’ boobs are even more important.
Please give $1, $5, $100, whatever you can give for this worthy cause (and I’m pretty sure Tracy will show us her new anatomy when she’s done!)
Cancer sucks. I don’t guess I’m going too far out on a limb, saying that. 🙂 CLICK HERE TO DONATE TO TRACY’S TITS.
yr obt svt,
Dr Steve
June 15, 2015
RexDart Update
It is with great sadness that I report that our friend of many months, RexDart, AKA Jeff Zurio, succumbed to his metastatic cancer earlier in the month. Fred from Brooklyn and I had kept in touch with him and when I last spoke with him he was in good spirits with good pain control. He had friends in El Paso who were going to actually care for him so he wouldn’t be alone. After that phone call, we lost all contact with Jeff.
One thing Jeff told me (many times, actually) was that the support, both financially and emotionally, from Weird Medicine, O&J and interrobang.com fans was the only thing that kept him going his last few months. Thank you all for being such great, great people; this shows that even a little effort by a lot of people can ease suffering and improve quality of life in people that we’ve never even met. Amazing.
yr obt svt,
Steve
You Don’t Want to Miss This!
Catch a Rising StaratOcean State Theatrepresents |
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Rob Bartlett & Tony Powell
Saturday, June 27 at 7:30pm
Tickets: $42 – Standard Seating |
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Rob started in stand-up comedy at Richard M. Dixon’s White House Inn, a talent showcase club on New York’s Long Island run by the presidential look-alike. He has headlined at the Sands Hotel and Casino in Las Vegas, Atlantic City’s Tropicana and Hilton Hotels, Mohegan Sun and Foxwoods Resort and Casino. On television, Rob has appeared as a stand up comedian on the “MTV Half Hour Comedy Hour,” “Standup Spotlight” on VH1 and on “Late Night with David Letterman” and “Conan O’Brien.”
In 1986, Rob became a regular in-studio guest of Don Imus at radio station WNBC 66AM. When the station was sold and the Imus in The Morning Program moved to the WFAN studios in Astoria, Rob became a contract player, and has since written and performed some of the show’s popular cast of characters. He has brought some of them, such as Brian Wilson of the Beach Boys, Camilla Parker Bowles, former president Bill Clinton and Dr. Phil to the new Imus In the Morning set at MSNBC. Rob’s television credits include starring roles on the Paramount/CBS comedy special “What’s Alan Watching?,” ABC’s “Move the Crowd,” and a recurring role on NBC as attorney Milton Schoenfeld on “Law & Order, Special Victims Unit.” Rob is very proud to have been voted one of the “Top Ten Worst” wrestling announcers in history for his short-lived stint at color commentator of the WWF Monday Night Raw. He is also the voice of Marty, the hyperactive dog, on the popular cartoon series “Kenny the Shark”.
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Veteran stand-up comic/writer Tony Powell can be seen and heard weekday mornings on the nationally syndicated radio program “The Imus in the Morning Show” which is also simulcast on the Fox Business Channel on cable television and Direct TV. His television appearances include USA Live on USA Networks, “A&E Comedy on the Road” and NBC’s “Showtime at the Apollo” to name a few. Tony has appeared in several national commercials including Visa All Star Café with Andre Agassi, Ritz Crackers, Dawn Dishwashing Liquid, Fila, Heineken, and he was also the national radio spokesperson for both the Miller Genuine Draft and U.S. Army. As a stand-up comedian Tony has worked as a warm-up for Bill Cosby and Nickelodeon’s “Keenan and Kel”. He has performed in the nation’s premier comedy clubs. The Improv in Santa Monica, CA, The Ice House in Pasadena, CA,Charlie Goodnights in North Carolina, Gotham Comedy Club, The Comic Strip, Carolines, Dangerfields, all in New York City are just a few of the venues in which Tony has shared his comedic gifts . He’s opened for major recording artists such as O’Jays, Spinners, Whispers, The Jets, GQ and The Platters. He’s been a regular at The Cesear Pocono Resorts, The Tropicana and Taj Mahal in Atlantic City.
A Brooklyn native, Tony excelled academically and at the age of thirteen was accepted into the prestigious Choate Rosemary Hall boarding school. At sixteen he attended The University of Virginia where he earned his Bachelor of Arts degree in Rhetoric Communications.
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| click logo below for more info on Catch a Rising Star |
click picture below for more info on Rob Bartlett |
click picture below for more info on Tony Powell |
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March 25, 2015
RexDart Update
We have a listener who has been battling terminal bladder cancer since 2011. He’s had to try to continue to work just to keep the lights on despite horrific intractable pain, but hasn’t had a full time job since being laid off in 2012. A few months ago he told me “i’m already $100 away from being homeless. At this point I long for the relief that death will bring.”
Recently he was admitted with intractable bleeding from his bladder, causing blood clots that obstructed his urethra, causing horrific pain. A large catheter with three tubes in it did continuous irrigation to clean his bladder out. Being admitted wiped out his account and he has $1000/month in bills on a $700/month income.
He has no family who can help him, and he’s alone, suffering in a cold house trying to live on $700 a month. He finally has an oncologist who will TRY to treat him, but the chemo is keeping him from working and he just got admitted to the hospital with a blood sugar of 700.
He got better for awhile and we stopped raising money for him; he’s again bed ridden and can’t work. Eventually he will need hospice but the docs think they might be able to kick this thing back a bit if he can just make it to the treatments and stay out of the hospital.
Please donate below, $5, $10, $100, whatever you can afford; 100% will go to RexDart who is known to people on the Interrobang website and on twitter as @rexdart936.
Let’s see what we can do as a group to keep the lights on and some heat going so our friend can live out his days in peace.
March 5, 2015
Abscopal Effect and Malignant Melanoma
[This one is a rare effect, but if they can just figure out how to trigger it consistently (research is ongoing) this would be a kickass weapon in the war against malignant melanoma and some other cancers. A more general article on the abscopal effect can be found on Wikipedia, but here’s a quickie from Oncology Nurse Advisor. –dr steve]
A recent melanoma case featuring the abscopal effect, in which local radiotherapy delivered to a single tumor results in the regression of metastatic cancer at a distance from the irradiated site, may lay the groundwork for a promising approach to melanoma treatment.
Although the abscopal effect is extremely rare, it has been described in several cases of melanoma, lymphoma, and kidney cancer, according to a statement from Memorial Sloan-Kettering Cancer Center (MSKCC) in New York, New York. MSKCC medical oncologist Jedd Wolchok, MD, PhD, was senior author of the report describing the recent case (N Engl J Med. 2012;366-925931).
“We are excited about these results, and what we have seen in this one patient proves the principle that adding radiation therapy to immunotherapy may be a promising combination approach to treatment for advanced cancer,” commented Wolchok.
Wolchok’s team used ipilimumab, an immunotherapy, to treat a patient with advanced melanoma. Approved by the FDA in March 2011, ipilimumab is the first drug to demonstrate improved overall survival in persons with advanced melanoma. This monoclonal antibody works by inhibiting an immunologic checkpoint on T cells known as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4).
Over time, Wolchok’s patient’s melanoma had metastasized to the spleen, lymph nodes, and near the spine. When localized radiation was administered to the tumor near the spine to provide pain relief, the targeted tumor shrank significantly—and, unexpectedly, so did the tumors in the spleen and the lymph nodes, even though those sites were not directly targeted by the radiation therapy. The use of radiation therapy also resulted in other changes that allowed the patient’s immune system to recognize and control the cancerous cells more effectively.
The researchers followed the patient from her initial diagnosis of melanoma in 2004 through a series of treatments and eventual disease regression in April 2011 after a combination treatment of radiation and immunotherapy.
Measles and Multiple Myeloma
[Another interesting idea…if you know someone with refractory multiple myeloma, they may qualify for a clinical trial in vaccine therapy (take THAT, anti-vaxxers!) –dr steve]
from cnn.com
A woman with an incurable cancer is now in remission, thanks, doctors say, to a highly concentrated dose of the measles virus.
For 10 years, Stacy Erholtz, 49, battled multiple myeloma, a deadly cancer of the blood. Doctors at the Mayo Clinic say she had received every type of chemotherapy drug available for her cancer and had undergone two stem cell transplants, only to relapse time and again.
Then researchers gave her and five other multiple myeloma patients a dose of a highly concentrated, lab-engineered measles virus similar to the measles vaccine. In fact, the dose Erholtz received contained enough of the virus to vaccinate approximately 10 million people.
“The idea here is that a virus can be trained to specifically damage a cancer and to leave other tissues in the body unharmed,” said the lead study author, Dr. Stephen Russell.
It’s a concept known as virotherapy, and it’s been done before. Mayo Clinic scientists say thousands of cancer patients have been treated with viruses, but this is the first case of a patient with a cancer that had spread throughout the body going into remission.
Erholtz was cancer-free for nine months.
“I think we succeeded because we pushed the dose higher than others have pushed it,” Russell said. “And I think that is critical. The amount of virus that’s in the bloodstream really is the driver of how much gets into the tumors.”
In simple terms, the measles virus makes cancer cells join together and explode, Mayo Clinic researcher Dr. Angela Dispenzieri explains. There’s also some evidence to suggest, she says, that the virus is stimulating the patient’s immune system, helping it recognize any recurring cancer cells and “mop that up.”
This treatment is still in the early testing stages, though. Doctors recently used radiation therapy to treat a small, localized tumor in Erholtz’s body.
And the other patients in the trial did not go into remission. Tests showed the virus helped shrink one woman’s tumors, but they started growing again soon after. The other patients’ cancers did not respond to the treatment.
Researchers also don’t know whether this virotherapy will help other patients or whether it can be applied to other types of cancer. The measles virus worked with these multiple myeloma patients because they are already immune-deficient, meaning their bodies can’t fight off the virus before it has a chance to attack the cancer cells.
More of the highly concentrated measles virus is being created now to be used in a larger clinical trial, Mayo Clinic researchers say. They’ve developed a manufacturing process that can produce large amounts of the virus, Russell says.
“We recently have begun to think about the idea of a single shot cure for cancer — and that’s our goal with this therapy,” he said.
Striking Results With T-Cell Immunotherapy in Cervical Cancer
[I used to say we were 100 years away from a more generalized approach to cancer therapy. In the end, barring some unforeseen breakthrough, cancer “cures” will come from the realm of immunology. The immune system is perfectly appointed to eradicate cancer cell by cell, molecule by molecule, but it only works if it actually recognizes the cancer as abnormal. Turning on the immune system to recognize cancer cells as foreign is the purpose of a lot of research right now and this is the outcome of a small pilot study. This makes me think the time horizon is much less than 100 years. Stay tuned for more; I’ll post new articles as I find them. –Dr Steve]
CHICAGO ? The data are preliminary, but the results are striking, demonstrating that an immunotherapy approach using adoptive T-cell therapy may have a role in the treatment of advanced cervical cancer.
A single infusion of the T-cell therapy induced a complete and durable remission in 2 patients with advanced metastatic cervical cancer. In addition, a third patient achieved a partial response of 3 months’ duration, with a 39% reduction in tumor volume.
“This study shows that complete and durable tumor regression can occur following a single infusion of HPV [human papillomavirus]–targeted tumor-infiltrating T cells,” said lead study author Christian Hinrichs, MD, an assistant clinical investigator at the National Cancer Institute.
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Dr. Christian Hinrichs
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As of last week, he noted, the 2 patients remain in complete remission and are now at 15 and 22 months after treatment.
Speaking at a press briefing during the 2014 Annual Meeting of the American Society of Clinical Oncology, Dr. Hinrichs explained that new therapies are needed for metastatic cervical cancer, because chemotherapy is not curative and rarely provides durable palliation.
“Cervical cancer harbors attractive targets for immunotherapy for the HPV E6 and E7 oncoproteins, but clinical trials in immunotherapy for this disease have been disappointing at this time,” he said.
Adoptive T-cell therapy is an emerging and promising immunotherapy platform, Dr. Hinrichs explained, but its study in epithelial cancers has really been limited, and it has not been studied in cervical therapy.
Objective and Durable Responses
Dr. Hinrichs and colleagues evaluated the use of adoptive T-cell therapy in carcinoma of the uterine cervix, a virally induced malignancy that constitutively expresses the HPV E6 and E7 oncoproteins. They conducted a small trial that included 9 patients with metastatic HPV-positive cancers, and treated them with tumor-infiltrating lymphocytes (TIL) selected for HPV-E6 and -E7 reactivity (HPV-TIL).
All patients received a median of 81 x 109 T cells (range, 33 to 159 x 109) as a single infusion, and the infused cells possessed reactivity against high-risk HPV E6 and/or E7 in 6 of 8 patients. There were 2 patients with no HPV reactivity, and they did not respond to treatment.
Treatment with HPV-TIL infusion was preceded by nonmyeloablative conditioning and was followed by high-dose bolus aldesleukin (Proleukin, Chiron Corporation), an interleukin-2-like product.
Of the 6 patients with HPV reactivity, 3 experienced objective tumor responses by RECIST, 1 partial response and 2 complete responses.
One patient with a complete response was a 36-year-old woman with chemotherapy-refractory HPV-16+ squamous cell carcinoma. “She had been treated with 3 different cytotoxic chemotherapy regimens and had multiple tumor sites, and had a complete response and no evidence of disease at 18 months, and her scans at 22 months look the same,” said Dr. Hinrichs.
The other patient who achieved a complete response was also 36 years old and had chemoradiation-refractory HPV-18+ adenocarcinoma. “Her primary tumor was very aggressive, and at the time of surgery, it was found to have spread to the pelvis and distant sites,” he explained. “She had a complete regression, for 15 months now.”
Both patients also demonstrated prolonged repopulation with HPV-reactive T cells following their treatment, and increased frequencies of HPV-specific T cells were detectable after 13 months in 1 patient and 6 months in the other. Conversely, 2 patients with HPV-reactive TIL that did not respond to treatment did not display repopulation with HPV-reactive T cells.
The most common adverse events were hematologic, and the other most common toxicity was related to infection, Dr. Hinrichs pointed out, with about half of patients experiencing febrile neutropenia. None of the patients had infusion reactions, and all of the hematologic events were completely reversible.
“This study offers proof of principle that immunotherapy can induce regression of cervical cancer and that adoptive T-cell therapy can mediate regression of epithelial cancer,” Dr. Hinrichs concluded. “Continued investigation of HPV-TIL for metastatic cervical cancer is warranted.”
He added that they plan to expand the trial to 35 patients and that there is a separate cohort for noncervical HPV-related cancers.
Exciting Despite Small Numbers
Two experts have expressed enthusiasm over these results.
“This is a very hard group to treat, and if the disease recurs, they essentially have zero survival,” commented David O’Malley, MD, gynecologic oncologist and assistant professor, Ohio State University Comprehensive Cancer Center, the Arthur G. James Cancer Hospital, and the Richard J. Solove Research Institute, Columbus. “So anything that offers the possibility of a complete response is very exciting.”
However, these results have to be taken in the context of a very small trial as well as a fairly toxic regimen that is very expensive to initiate, he told Medscape Medical News. “But if these responses are found to be durable, then this is an exciting new avenue to pursue for these women with little to no choices.”
Michael Birrer, MD, PhD, director of medical gynecologic oncology, Gynecologic Oncology Research Program, Massachusetts General Hospital in Boston, agreed that these results were exciting, despite the limited number of patients.
“For metastatic cervical cancer, the prognosis is amazingly dim, with what used to be about a 3.7-month survival now has been extended to about 6 months with bevacizumab [Avastin, Genentech, Inc],” he said. “But it is uniformly fatal. Still, we don’t see complete remissions, and we certainly don’t see prolonged remissions. So despite the small numbers, this is quite provocative and quite interesting.
“On top of that, this is an immune therapy intervention which has been around a long time, but there is a renewed interest in it because of the PD-1 drugs,” Dr. Birrer continued. “But because this is a viral propagated disease with HPV as the target, it all makes sense. Even though the numbers are small, I think a lot of us are quite excited about it.”
This study was supported by the National Cancer Institute, National Institutes of Health. The authors have disclosed no relevant financial relationships.
2014 Annual Meeting of the American Society of Clinical Oncology: Abstract LBA3008. Presented June 3, 2014.
Medscape Medical News © 2014 WebMD, LLC
February 8, 2015
Eat Fiber and Die – 1987
Ok, I recorded this in my little bedroom studio in 1987 with a Korg DSS-1 sampling synthesizer. I was an idiot. There was overwhelming response to this being played on my show (none of it positive, mind you) so I thought I’d post it here for your non-enjoyment. Drive your significant other crazy with it, pretending to like it.
It’s titled “Eat Fiber and DIE” for no other reason than hipsters were (correctly) extolling the virtues of fiber at the time and I was an ass. If you can’t understand it, the refrain is “Someone roll me a GREAT BIG ‘SPLEEF’, in return I’ll give you MANUAL RELIEF!”
At the time, there were “massage parlors” all over my area that advertised “Manual Relief” in signs outside their little trailers that they stacked up all up and down the highway just into the county. Once the county made handjobs illegal, the parlors went away, but the euphemism never left me.
yr obt svt,
Dr Steve
PS: Here are the lyrics:
There’s a lot of things that I would like to say
I’d like to talk to you, talk to you today
There’s a lot of scary things happening in this world
It’s a scary scary scary kind of world
Someone roll me a great big spliff
In return I’ll give you manual relief
Someone roll me a great big spliff
Madman options
French fried dough
You don’t read the papers,
So what do you know?
You think kickin’ ass be cool…
…shove a bomb up your ass, cut off your tool.
There’s a lot of things, I’d like to say to you
But you won’t listen, won’t listen, won’t listen, will you?
You bitch about the world’s a piece of shit
But you won’t do nothing about it, go suck your mama’s tit.
Someone roll me a great big spliff…
As long as you’re just pissin’
Ain’t no one gonna listen.
Do something about it.
Get up, get up, get off your brush head ass
Go fucking run for mayor or something, I dunno.
There’s a lot of things that I would like to say
I’d like to talk to you today
There’s a lot of scary things happening in this world
It’s a kind of scary kind of world
Someone roll me a great big spliff…
February 1, 2015
Recipe: Cheesy No Grain Breadsticks
I’m going to create a new category of NSNG recipes as I find and test them. I tried this one SuperBowl Sunday and even my kids thought it was pretty good. It ends up with a soft, bread-y interior, with a crisp outside crust (made of cheese). Dip it in marinara or eat it with NSNG chili, as we did. I’ll be using this basic recipe for pizza crust in the future.
1 large head of cauliflower
4 eggs
1 1/2 cups mozzarella, shredded, divided into 2 parts
1 cups cheddar cheese, shredded
1-2 tsp dried oregano
1 tsp minced garlic
1/2 tsp salt
You can use more or less cheese, just experiment with the proportions.
Preheat oven to 425 degrees Fahrenheit, 400 if a convection oven. Cut up the cauliflower into medium sized florets and place in a pot with 1″ water in the bottom. Turn on high and steam the cauliflower for 10 minutes, covered, after the water starts to boil. Turn out the cauliflower into a colander and drain for a few minutes. Transfer the cauliflower into a bowl and smash it with a potato masher until it is the size and consistency of rice.
Add the eggs, half the mozzarella, the cheddar, oregano, garlic and salt. Mix thoroughly and turn out onto a large cookie sheet lined with parchment paper. The “dough” will be liquidy but shapeable.
Bake for 25 minutes, or until the dough is uniformly golden-brown. Top with remaining mozzarella and bake again until golden-brown, usually 5-7 minutes.
Remove and cut into pieces and let cool for a couple of minutes before serving plain or with marinara dip.
Yours will look something like this, though this is a stock photo 🙂
Let me know if you like it! Cauliflower sounds horrendous but it’s amazing how little taste it has and how easy it is to fool your palate into actually enjoying it.
yr obt svt,
Steve
[editor’s note: Dr Steve is not pushing one “diet” or another…choose a dietary lifestyle based on your own needs and tastes. If you’re interested in NSNG lifestyle, check out Vinnie Tortorich’s website.]
